Abstract

Aim: To examine the relationship between complete blood count metrics and the severity of coronary artery disease (CAD) in patients undergoing coronary angiography.

Methods: Patients diagnosed with stable angina pectoris or acute coronary syndrome by coronary angiography between October 2018 and February 2019 were included in the study. Based on their angiography results, patients were divided into two groups: one with severe CAD (n=258) and one with non-severe CAD (n=219). The initial clinical characteristics, along with data from laboratory tests and complete blood counts, were recorded and compared between the two groups.

Results: The Wight Blood Cell (WBC) count, Neutrophil (NEU) count, Monocyte/Lymphocyte Ratio (MLR), Neutrophil/Lymphocyte Ratio (NLR), Monocyte/High-Density Lipoprotein Cholesterol Ratio (MHR), systemic immune inflammation index (SII) and systemic inflammation response index (SIRI) were each significantly higher in the group with severe CAD than in the group without severe CAD. The analysis utilized logistic regression, factoring in recognized CAD risk factors such as age, gender, diabetes mellitus (DM), hypertension (HT), hyperlipidemia (HL), and smoking, identified NLR, MHR, MLR, SII, and SIRI as notable and independent indicators of severe CAD.

Conclusion: Our study showed that since it was an independent predictor of CAD, SII and SIRI could be utilized as a novel indicator for assessing the severity of CAD.

Keywords: complete blood count, coronary artery disease, inflammation, systemic immune inflammation index, systemic inflammation response index

Copyright and license

Copyright © 1970 The Author(s). This is an open-access article published by Bolu İzzet Baysal Training and Research Hospital under the terms of the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.

How to cite

1.
Bayraktar MF, Coşgun M. Can the systemic immune inflammation index (SII) and the systemic inflammation response index (SIRI) predict the severity of coronary artery disease?. Northwestern Med J. 2024;4(3):157-62. https://doi.org/10.54307/2024.NWMJ.116

References

  1. Go AS, Mozaffarian D, Roger VL, et al. Heart disease and stroke statistics-2014 update: a report from the American Heart Association. Circulation. 2014; 129(3): e28-292. https://doi.org/10.1161/01.cir.0000441139.02102.80
  2. Lima Dos Santos CC, Matharoo AS, Pinzón Cueva E, et al. The Influence of Sex, Age, and Race on Coronary Artery Disease: A Narrative Review. Cureus. 2023; 15(10): e47799. https://doi.org/10.7759/cureus.47799
  3. Elieh-Ali-Komi D, Bot I, Rodríguez-González M, Maurer M. Cellular and Molecular Mechanisms of Mast Cells in Atherosclerotic Plaque Progression and Destabilization. Clin Rev Allergy Immunol. 2024; 66(1): 30-49. https://doi.org/10.1007/s12016-024-08981-9
  4. Haybar H, Shokuhian M, Bagheri M, Davari N, Saki N. Involvement of circulating inflammatory factors in prognosis and risk of cardiovascular disease. J Mol Cell Cardiol. 2019; 132: 110-9. https://doi.org/10.1016/j.yjmcc.2019.05.010
  5. Sit M, Aktas G, Ozer B, et al. Mean platelet volume: an overlooked herald of malignant thyroid nodules. Acta Clin Croat. 2019; 58(3): 417-20. https://doi.org/10.20471/acc.2019.58.03.03
  6. Sincer I, Çekici Y, Cosgun M, et al. Does Mean Platelet Volume Decrease in the presence of Coronary Artery Fistula? Arq Bras Cardiol. 2019; 113(1): 71-6. https://doi.org/10.5935/abc.20190088
  7. Chen Y, Chen S, Han Y, Xu Q, Zhao X. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio are Important Indicators for Predicting in-Hospital Death in Elderly AMI Patients. J Inflamm Res. 2023; 16: 2051-61. https://doi.org/10.2147/JIR.S411086
  8. Jin Z, Wu Q, Chen S, et al. The associations of two novel inflammation indexes, SII and SIRI with the risks for cardiovascular diseases and all-cause mortality: a ten-year follow-up study in 85,154 individuals. J Inflamm Res. 2021; 14: 131-40. https://doi.org/10.2147/JIR.S283835
  9. Yildiz C, Yuksel Y, Rakici IT, Katkat F, Ayça B, Turhan Çağlar FN. Assessment of systemic immune-inflammation index and systemic inflammation-response index in different coronary artery plaque types. Angiology. 2023; 74(6): 536-44. https://doi.org/10.1177/00033197231158937
  10. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med. 1999; 340(2): 115-26. https://doi.org/10.1056/NEJM199901143400207
  11. Uysal HB, Dağlı B, Akgüllü C, et al. Blood count parameters can predict the severity of coronary artery disease. Korean J Intern Med. 2016; 31(6): 1093-100. https://doi.org/10.3904/kjim.2015.199
  12. Arbel Y, Finkelstein A, Halkin A, et al. Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography. Atherosclerosis. 2012; 225(2): 456-60. https://doi.org/10.1016/j.atherosclerosis.2012.09.009
  13. Wang X, Zhang G, Jiang X, Zhu H, Lu Z, Xu L. Neutrophil to lymphocyte ratio in relation to risk of all-cause mortality and cardiovascular events among patients undergoing angiography or cardiac revascularization: a meta-analysis of observational studies. Atherosclerosis. 2014; 234(1): 206-13. https://doi.org/10.1016/j.atherosclerosis.2014.03.003
  14. Xia Y, Xia C, Wu L, Li Z, Li H, Zhang J. Systemic Immune Inflammation Index (SII), System Inflammation Response Index (SIRI) and risk of all-cause mortality and cardiovascular mortality: a 20-year follow-up cohort study of 42,875 US adults. J Clin Med. 2023; 12(3): 1128. https://doi.org/10.3390/jcm12031128
  15. Wei X, Zhang Z, Wei J, Luo C. Association of systemic immune inflammation index and system inflammation response index with clinical risk of acute myocardial infarction. Front Cardiovasc Med. 2023; 10: 1248655. https://doi.org/10.3389/fcvm.2023.1248655
  16. Dziedzic EA, Gąsior JS, Tuzimek A, et al. Investigation of the associations of novel inflammatory biomarkers-Systemic Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI)-With the severity of coronary artery disease and acute coronary syndrome occurrence. Int J Mol Sci. 2022; 23(17): 9553. https://doi.org/10.3390/ijms23179553
  17. Candemir M, Kiziltunç E, Nurkoç S, Şahinarslan A. Relationship Between Systemic Immune-Inflammation Index (SII) and the Severity of Stable Coronary Artery Disease. Angiology. 2021; 72(6): 575-81. https://doi.org/10.1177/0003319720987743
  18. Liu Y, Ye T, Chen L, et al. Systemic immune-inflammation index predicts the severity of coronary stenosis in patients with coronary heart disease. Coron Artery Dis. 2021; 32(8): 715-20. https://doi.org/10.1097/MCA.0000000000001037