Abstract
Paroxysmal sympathetic hyperactivity (PSH) is a state of autonomic dysfunction characterized by symptoms such as tachypnea, tachycardia, hypertension, hyperthermia, sweating, and dystonia. It can occur after traumatic brain injury, hypoxic-ischemic encephalopathy, and diseases such as stroke. Hypoxia, extensive axonal damage, and young age are believed to predispose to the development of PSH. These patients may be diagnosed with pulmonary embolism, septicemia, or epileptic seizures. Delays in diagnosis prolong hospital stay. Here, we present an 81-year-old man who developed PSH after a recurrent stroke and our management.
Keywords: Paroxysmal sympathetic hyperactivity, Ischemic stroke, Autonomic dysfunction
Copyright and license
Copyright © 2024 The Author(s). This is an open-access article published by Bolu İzzet Baysal Training and Research Hospital under the terms of the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.
How to cite
References
- Baguley IJ, Perkes IE, Fernandez-Ortega JF, et al. Paroxysmal sympathetic hyperactivity after acquired brain injury: consensus on conceptual definition, nomenclature, and diagnostic criteria. J Neurotrauma. 2014; 31(17): 1515-20. https://doi.org/10.1089/neu.2013.3301
- Rabinstein AA. Paroxysmal sympathetic hyperactivity in the neurological intensive care unit. Neurol Res. 2007; 29(7): 680-2. https://doi.org/10.1179/016164107X240071
- Perkes I, Baguley IJ, Nott MT, Menon DK. A review of paroxysmal sympathetic hyperactivity after acquired brain injury. Ann Neurol. 2010; 68(2): 126-35. https://doi.org/10.1002/ana.22066
- Hendricks HT, Heeren AH, Vos PE. Dysautonomia after severe traumatic brain injury. Eur J Neurol. 2010; 17(9): 1172-7. https://doi.org/10.1111/j.1468-1331.2010.02989.x
- Choi HA, Jeon SB, Samuel S, Allison T, Lee K. Paroxysmal sympathetic hyperactivity after acute brain injury. Curr Neurol Neurosci Rep. 2013; 13(8): 370. https://doi.org/10.1007/s11910-013-0370-3
- Baguley IJ, Heriseanu RE, Cameron ID, Nott MT, Slewa-Younan S. A critical review of the pathophysiology of dysautonomia following traumatic brain injury. Neurocrit Care. 2007; 8: 293-300. https://doi.org/10.1007/s12028-007-9021-3
- Meyfroidt G, Baguley IJ, Menon DK. Paroxysmal sympathetic hyperactivity: the storm after acute brain injury. Lancet Neurol. 2017; 16(9): 721-9. https://doi.org/10.1016/S1474-4422(17)30259-4
- Gao B, Pollock JA, Hinson HE. Paroxysmal sympathetic hyperactivity in hemispheric intraparenchymal hemorrhage. Ann Clin Transl Neurol. 2014; 1(3): 215-9. https://doi.org/10.1002/acn3.44
- Kitagawa T, Ishikawa H, Yamamoto J, Ota S. Takotsubo cardiomyopathy and neurogenic pulmonary edema after carotid endarterectomy. World Neurosurg. 2019; 124: 157-60. https://doi.org/10.1016/j.wneu.2018.12.206
- Fernandez-Ortega JF, Baguley IJ, Gates TA, Garcia-Caballero M, Quesada-Garcia JG, Prieto-Palomino MA. Catecholamines and paroxysmal sympathetic hyperactivity after traumatic brain injury. J Neurotrauma. 2017; 34(1): 109-14. https://doi.org/10.1089/neu.2015.4364
- Burton JM, Morozova OM. Calming the storm: dysautonomia for the pediatrician. Curr Probl Pediatr Adolesc Health Care. 2017; 47(7): 145-50. https://doi.org/10.1016/j.cppeds.2017.06.009
- Feng Y, Zheng X, Fang Z. Treatment progress of paroxysmal sympathetic hyperactivity after acquired brain injury. Pediatr Neurosurg. 2015; 50(6): 301-9. https://doi.org/10.1159/000439282
- Samuel S, Allison TA, Lee K, Choi HA. Pharmacologic management of paroxysmal sympathetic hyperactivity after brain injury. J Neurosci Nurs. 2016; 48(2): 82-9. https://doi.org/10.1097/JNN.0000000000000207