Aim: Cancer has been the most lethal disease globally, notably in the last century. Each type of cancer and the response of cancer cells to treatment is unique motivates scientists to conduct new studies every day. Due to accumulating mutations, existing drugs, particularly those intended to treat cancer, are insufficient in treating cancer. This creates a strong need for research to discover new molecules or increase drug efficacy in cancer treatment. Regarding the development of alternative anticancer drugs, plant-derived agents stand out for their correlation with cancer. The flavonoids included in the fruits and vegetables we eat daily are thought to play a role in cancer prevention and provide new therapeutic options. Flavonoids are thermostable polyphenolic compounds commonly found in nature. In our study, the Phloridzin flavonoid obtained from apples, a fruit that we consume a lot in our daily life, has been tested on different cell lines such as MDAMB231, MCF-7, 293T, 22RV1, U87, A549, and it has been tested whether it has a cytotoxic effect. We observed that Phloridzin exhibited selective cytotoxicity in these cancer cells. We hope that this research will shed light on further research on the mechanism of death of Phloridzin and its use as an alternative to cancer treatment.

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Keywords: cancer, phenolic compounds, phloridzin, cytotoxicity, MDAMB231, MCF-7, 22RV1, U87, A549