Aim: The present study aimed to review the association of Monocyte/High-Density Lipoprotein (HDL) ratio (MHR) in patients with and without stenosis who had angiography due to preliminary diagnosis of unstable angina pectoris (USAP) and evaluate the diagnostic value of MHR for diagnosis of USAP with stenosis. (stenosis requiring intervention (≥50%) and stenosis not requiring intervention (<50%).

Methods: The patients admitted due to USAP diagnosis and presented stenosis above 50% in the angiography (Group 1), and the patients who presented stenosis below 50% (Group 2) were compared. Age, gender, co-morbidity, smoking habits, hemogram parameters, cholesterol levels before angiography, MHR, and mortality states were reviewed.

Results: The median age of the patients in Group 1 was 61 (IQR: 20), and 71.6% of the patients were male. The median MHR in Group 1 and Group 2 were 0.02 (IQR: 0.01) and 0.01 (IQR: 0.0), respectively. MHR of the patients with stenosis above 50% was significantly higher (p<0.05). Sensitivity and specificity were detected at 83.2% and 82.6%, respectively, for a cut-off value of 0.014 for determination of stenosis above 50% in the present study (EAA 0.879; 95% CI 0.817-0.941).

Conclusion: We believe that MHR may be a parameter to determine mine the degree of stenosis in patients with a preliminary diagnosis of USAP. The intervention requirement of the opinion that MHR has a high predictability power for indicating of degree of stenosis has arisen in our mind with this study.

Keywords: monocyte, high-density lipoprotein, monocyte to high-density lipoprotein ratio, unstable angina pectoris