Drug-Resistant Epilepsy is the continuation of seizures despite administering two tolerable antiepileptic drugs at the appropriate dose and time, which are selected according to the type of seizure. Growth retardation, focal neurological findings, organic brain lesions, specific EEG disorders, and epilepsy in the family are risk factors for resistant epilepsy. Tuberous sclerosis is a multisystemic and autosomal dominant genetic disease with hamartomas in many organs such as the skin, central nervous system, kidney, and lungs. Brain hamartomas and other central nervous system lesions cause resistant epilepsy in tuberous sclerosis. In this article, we present a 16-year-old patient with tuberous sclerosis who was followed up with the diagnosis of resistant epilepsy, despite typical physical examination findings. This research emphasised that tuberous sclerosis should be kept in mind in the aetiology of resistant epilepsy and how important physical examination is.

Keywords: tuberous sclerosis, resistant epilepsy, TSC2 gene