Abstract

Aim: This study aims to investigate the effect of BioGlue (BG) in preventing cellular damage due to pressure increase in saphenous vein grafts (SVGs) used in coronary artery surgery.

Methods: Twenty volunteers were accepted into this ex vivo study. SVGs were kept in circulation in the cardiopulmonary bypass (CPB) machine for 60 minutes at a pressure of 120 mmHg and a flow rate of 250 ml/min.

Results: In the BG treatment group; Type 1 endothelial damage was observed in five samples (25%), Type 2 endothelial damage in nine samples (45%), and Type 3 endothelial damage in two samples (10%). No endothelial damage was observed in 4 samples.

Conclusion: It was observed that the application of BG on the saphenous vein graft under high pressure did not cause endothelial damage due to tissue stiffness that developed.

Keywords: Coronary artery disease, endothelial damage, saphenous vein graft

Copyright and license

Copyright © 2023 The Author(s). This is an open-access article published by Bolu İzzet Baysal Training and Research Hospital under the terms of the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.

How to cite

1.
Badem S, Kahraman N. What is the effect of Bioglue® tissue adhesive on saphenous vein graft endothelium exposed to high pressure? An experimental model. Northwestern Med J. 2023;3(1):31-7. https://doi.org/10.54307/NWMJ.2023.33042

References

  1. Sohn SH, Kim SH, Hwang HY, Kim K-B. Mid-Term Outcomes and Angiographic Patency of Redo Coronary Artery Bypass Grafting: A Comparison between Off-Pump and On-Pump Surgery. J Chest Surg. 2021; 54(2): 106-16. https://doi.org/10.5090/jcs.20.122
  2. Kouzi-Koliakos K, Kanellaki-Kyparissi M, Marinov G, et al. Prebypass histological and ultrastructural evaluation of the long saphenous vein as a predictor of early graft failure. Cardiovasc Pathol. 2006; 15(6): 336-46. https://doi.org/10.1016/j.carpath.2006.07.005
  3. Sur S, Sugimoto JT, Agrawal DK. Coronary artery bypass graft: why is the saphenous vein prone to intimal hyperplasia? Can J Physiol Pharmacol. 2014; 92(7): 531-45. https://doi.org/10.1139/cjpp-2013-0445
  4. Yang Q, Lei D, Huang S, et al. Effects of the different-sized external stents on vein graft intimal hyperplasia and inflammation. Ann Transl Med. 2020; 8(4): 102. https://doi.org/10.21037/atm.2020.01.16
  5. Wan S, Arifi AA, Chan MCW, et al. Differential, time-dependent effects of perivenous application of fibrin glue on medial thickening in porcine saphenous vein grafts. Eur J Cardiothorac Surg. 2006; 29(5): 742-6; discussion 747. https://doi.org/10.1016/j.ejcts.2005.12.059
  6. Kahraman N, Yumun G, Gücü A, et al. Administration of perivascular cyanoacrylate for the prevention of cellular damage in saphenous vein grafts: an experimental model. Cardiovasc J Afr. 2016; 27(3): 159-63. https://doi.org/10.5830/CVJA-2015-078
  7. Dai L, Gao M, Gu C, Zhang F, Yu Y. Perivenous application of cyanoacrylate tissue sealants reduces intimal and medial thickening of the vein graft and inflammatory responses in a rabbit model of carotid artery bypass grafting. Eur J Cardiothorac Surg. 2016; 49(2): 675-81. https://doi.org/10.1093/ejcts/ezv111
  8. Ip JH, Fuster V, Badimon L, Badimon J, Taubman MB, Chesebro JH. Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation. J Am Coll Cardiol. 1990; 15(7): 1667-87. https://doi.org/10.1016/0735-1097(90)92845-s
  9. Bhamidipati CM, Coselli JS, LeMaire SA. BioGlue in 2011: what is its role in cardiac surgery? J Extra Corpor Technol. 2012; 44(1): P6-12.
  10. Azadani AN, Matthews PB, Ge L, et al. Mechanical properties of surgical glues used in aortic root replacement. Ann Thorac Surg. 2009; 87(4): 1154-60. https://doi.org/10.1016/j.athoracsur.2008.12.072
  11. Stooker W, Niessen HWM, Wildevuur WR, et al. Perivenous application of fibrin glue reduces early injury to the human saphenous vein graft wall in an ex vivo model. Eur J Cardiothorac Surg. 2002; 21(2): 212-7. https://doi.org/10.1016/s1010-7940(01)01121-6
  12. Khan H, Chaubey S, Desai J. Early failure of coronary artery bypass grafts: an albumin cross-linked glutaraldehyde (BioGlue) related complication. J Card Surg. 2011; 26(3): 264-6. https://doi.org/10.1111/j.1540-8191.2011.01208.x
  13. Okazaki Y, Takarabe K, Murayama J, et al. Coronary endothelial damage during off-pump CABG related to coronary-clamping and gas insufflation. Eur J Cardiothorac Surg. 2001; 19(6): 834-9. https://doi.org/10.1016/s1010-7940(01)00708-4
  14. Slezak P, Klang A, Ferguson J, et al. Tissue reactions to polyethylene glycol and glutaraldehyde-based surgical sealants in a rabbit aorta model. J Biomater Appl. 2020; 34(9): 1330-40. https://doi.org/10.1177/0885328219900078