Abstract

Aim: We aimed to reveal the similarities and differences between the rare and severe multisystem inflammatory syndrome (MIS-C) and active familial Mediterranean fever (FMF) disease in children. Our study may help in the early recognition of MIS-C syndrome in children and distinguish it from other diseases with similar symptoms.

Methods: We evaluated the demographic and clinical characteristics, laboratory findings, treatments and outcomes of patients with MIS-C syndrome and active FMF.

Results: The clinical and laboratory findings of a total of 66 patients hospitalized in our pediatric clinic with the diagnosis of active FMF (n: 42) and MIS-C syndrome (n: 24) were reviewed retrospectively. The reason for pediatric emergency admission was determined as resistant fever in all patients. When the clinical findings of the patients were compared, it was determined that joint and abdominal pain in the FMF group and vomiting, rash, cough, Lenfadenopati (LAP) and myalgia findings in the MIS-C group were statistically significantly higher (p<0.05). When the laboratory findings were evaluated between the two groups, the lymphocyte count and vitamin D levels were statistically significantly lower, while the leukocyte count, glucose, C-reactive protein (CRP), ferritin, lactate dehydrogenase (LDH), sedimentation, aspartate aminotransferase (AST), alanine aminotransferase (ALT) were found to be significantly higher in the group with MIS-C syndrome (p<0.05 ).

Conclusion: We think that the results of our study may guide pediatricians and clinicians in the early differential diagnosis and management of MIS-C, by showing the similarities and differences among MIS-C patients from autoinflammatory diseases such as FMF.

Keywords: COVID-19, Familial Mediterranean fever, SARS-CoV-2

Copyright and license

Copyright © 2023 The Author(s). This is an open-access article published by Bolu İzzet Baysal Training and Research Hospital under the terms of the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.

How to cite

1.
Yoldaş MA, Çelebi Tayfur A, Hancı F, Danış A, Bolu S, Atasoy Hİ. Similarities and differences between familial Mediterranean fever (FMF) and multisystem inflammatory syndrome (MIS-C) in children. Northwestern Med J. 2023;3(2):74-80. https://doi.org/10.54307/NWMJ.2023.38039

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