Abstract

Aim: In this prospective study, our goal is to evaluate the effect of iodine-based contrast agent on renal Apparent Diffusion Coefficient (ADC) before and after the contrast agent in patients with normal and abnormal Glomerulary Filtration Rate (GFR) values using computed tomography (CT) imaging.

Methods: The patients who applied for CT examination at an age older than 40 years and met the inclusion criteria of patient and control groups were included. DWI was evaluated by two radiologist in the same session. The range of interest (ROI) was adjusted to be less than 1.5 cm².The Spearman correlation test was used for statistical analysis.

Results: A total of 48 subjects (23 and 25 subjects for patient and control groups, respectively) with two DWI scans were included. ADC values were compared for both kidneys before and after the administration of the contrast agent and a significant decrease in post-ADC values was observed in the control group (right kidney pre-ADC: 2,11±0,17 x10ˉ³, post-ADC 2,07±0,15 x10ˉ³ mm²/s, p=0,016; left kidney pre-ADC: 2,11±0,17 x10ˉ³ mm²/s, post-ADC 2,04±0,14 x10ˉ³ mm²/s, p=0,011). However, there was no significant difference between the patient groups according to the administration of contrast agent (right kidney pre-ADC: 1,97±0,22 x10ˉ³ mm²/s, post-ADC: 1,97±0,24 x10ˉ³ mm²/s, p=0,95; left kidney pre-ADC: 1,96±0,23 x10ˉ³ mm²/s, post-ADC: 1,98±0,22 x10ˉ³ mm²/s, p=0,64). Moreover, pre-ADC values in the patient group were relatively low. Pre-ADC values in both groups for the right kidney were 1,97±0,22 x10ˉ³ mm²/s and 2,11±0,17 x10ˉ³ mm²/s, respectively (p=0,016). Pre ADC values in both groups for the left kidney were 1,96±0,23 x10ˉ³ mm²/s and 2,11±0,17 x10ˉ³ mm²/s, respectively (p=0,018). No significant differences in the post-ADC values were observed between the two groups.

Conclusion: No decrease in ADC values was observed after the administration of iodine-based contrast agent in patients with a GFR less than 60, whereas there was a relatively high decrease in patients with normal GFR.

Keywords: Apparent diffusion coefficient, diffusion weighted MR imaging, glomerulary filtration rate

Copyright and license

Copyright © 2023 The Author(s). This is an open-access article published by Bolu İzzet Baysal Training and Research Hospital under the terms of the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.

How to cite

1.
Gür Özcan SG, Halıcıoğlu S, Tekçe H. Effect of Iodized contrast substances used in computed tomography examination on kidney apparent diffusion coefficient (ADC) value. Northwestern Med J. 2023;3(2):105-14. https://doi.org/10.54307/NWMJ.2023.57966

References

  1. Thoeny HC, De Keyzer F, Oyen RH, Peeters RR. Diffusion-weighted MR imaging of kidneys in healthy volunteers and patients with parenchymal diseases: initial experience. Radiology. 2005; 235(3): 911-7. https://doi.org/10.1148/radiol.2353040554
  2. Toya R, Naganawa S, Kawai H, Ikeda M. Correlation between estimated glomerular filtration rate (eGFR) and apparent diffusion coefficient (ADC) values of the kidneys. Magn Reson Med Sci. 2010; 9(2): 59-64. https://doi.org/10.2463/mrms.9.59
  3. Xu Y, Wang X, Jiang X. Relationship between the renal apparent diffusion coefficient and glomerular filtration rate: preliminary experience. J Magn Reson Imaging. 2007; 26(3): 678-81. https://doi.org/10.1002/jmri.20979
  4. Lerma VE, Berns SJ, Nissenson AR. Current Diagnosis & Treatment: Nephrology & Hypertension. McGraw Hill; 2009.
  5. Gleeson TG, Bulugahapitiya S. Contrast-induced nephropathy. AJR Am J Roentgenol. 2004; 183(6): 1673-89. https://doi.org/10.2214/ajr.183.6.01831673
  6. Bartorelli AL, Marenzi G. Contrast-induced nephropathy. J Interv Cardiol. 2008; 21(1): 74-85. https://doi.org/10.1111/j.1540-8183.2007.00318.x