Aim: Coronary artery disease (CAD) is a common manifestation of cardiovascular disease (CVD). The identification of reliable biomarkers for early CAD detection and risk assessment is crucial for effective prevention and management. This article examines the correlation between the uric acid to HDL cholesterol ratio (UHR) and the total calcium score (TCS) obtained from coronary CT angiography (CCTA) in the assessment of CAD.

Methods: The study included 60 patients (34 males and 26 females) without endocrine diseases or relevant medications to ensure a homogeneous population. Blood samples collected after an eight hour overnight fasting were analyzed for laboratory parameters. CCTA was performed using a standardized protocol. The total calcium score was calculated using established methods.

Results: The analysis showed a significant positive correlation between UHR and TCS (r=0.479, P=0.0001). Patients with coronary artery plaque had significantly higher UHR values compared to those without it (p = 0.001).

Conclusion: These findings suggest that UHR could serve as a promising biomarker for predicting CAD presence and severity, although further research is necessary to validate its clinical utility in CAD diagnosis and management.

Keywords: coronary artery disease, total calcium score, uric acid to HDL cholesterol ratio

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